What is the Ideal Setup for a site with 50K Uniques a day

[mubin]

50K Uniques a day
44K Files Downloaded per day
100 New Users Per day
2K File Uploads Per day
5Tb Per Day Bandwidth


Im thinking:

1) Web Server
1) Mysql Server
3-4) File Servers

Is that good or should i start with web and mysql on a single server?

I need at least 48TB of hard drive space for files so please consider that when mentioning file server options.


Please guys any and all help on what type of setup I should have would be appreciated.